Intergenerational, early life, cognitive and social determinants of eating disorders
Eating disorders (EDs): anorexia nervosa, bulimia nervosa and related disorders, are one of the leading causes of disease burden in young women. Better understanding of the interplay of parental, early life and psychosocial influences will generate important insights into the aetiology of these diseases and lead to more effective and equitable prevention and treatment strategies.
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Manager: Ilona Koupil
Period: 2010-01-01 - 2014-12-31
Funded by: Swedish Research Council (Medicine)
Description of the project
Within this project, we combine data from three longitudinal studies with a register-based study of the total Swedish population for analyses of determinants of incidence and long term outcomes of eating disorders.
In specific subprojects, we:
- investigate effects of grandparental and parental age and social characteristics on risk of eating disorders in children and grandchildren (females and males)
- address the role of family structure, sibling position, perinatal complications, school performance, social networks and aspirations, and parental health as a potential mediator or modifier of the effect of parental and grandparental social environment on eating disorders in offspring
- evaluate the effect of family social characteristics on long term outcome of eating disorders in men and women
- investigate mechanisms underlying the continuity in risk of psychiatric disease across generations (incl. effects of perinatal complications, school performance and peer status)
- investigate whether effects of social or health disadvantage are transmitted differentially through maternal and paternal lines
- attempt to generate evidence for effective and equitable prevention and treatment strategies.
The team is includes experts in paediatrics, public health medicine, psychiatry, psychology, sociology, epidemiology and statistics. The core research group is based at CHESS (Ilona Koupil, Jennie Ahrén Moonga, Flaminia Chiesa, Britt af Klinteberg, Anders Hjern) and Karolinska Institutet (Cecilia Magnusson, Christina Dalman, Sanna Tiikkaja). Our international collaborators are affiliated to the University of London, UK (Bianca de Stavola, Ulrike Schmidt and James MacCabe).
Do eating disorders in parents predict eating disorders in children? Evidence from a Swedish cohort.
Bould H, Sovio U, Koupil I, Dalman C, Micali N, Lewis G, Magnusson C. Acta Psychiatr Scand. 2015 Jan 9. doi: 10.1111/acps.12389. [Epub ahead of print]
Family history of education predicts eating disorders across multiple generations among 2 million Swedish males and females.
Goodman A, Heshmati A, Koupil I. PLoS One. 2014 Aug 27;9(8):e106475. doi: 10.1371/journal.pone.0106475. eCollection 2014.
Associations between birth characteristics and eating disorders across the life course: findings from 2 million males and females born in Sweden, 1975-1998.
Goodman A, Heshmati A, Malki N, Koupil I. Am J Epidemiol. 2014 Apr 1;179(7):852-63. doi: 10.1093/aje/kwt445. Epub 2014 Feb 18.
We are family--parents, siblings, and eating disorders in a prospective total-population study of 250,000 Swedish males and females.
Ahrén JC, Chiesa F, Koupil I, Magnusson C, Dalman C, Goodman A. Int J Eat Disord. 2013 Nov;46(7):693-700. doi: 10.1002/eat.22146. Epub 2013 Jun 6.
March 6, 2015
Page editor: Ylva Brännström Almquist
Source: Centre for Health Equity Studies (CHESS)